This is a Notice of Availability and Request for Comment from EPA's Office of Chemical Safety and Pollution Prevention regarding a white paper and draft memorandum titled 'Determining the Absence of Novel Proteins in the Saliva of Genetically Engineered Mosquitoes for Mosquito Control.' EPA is submitting these materials to the FIFRA Scientific Advisory Panel for peer review at a 3-day virtual public meeting on November 3 to 5, 2025. The documents address genetic design considerations and test methodologies to determine whether engineered proteins are absent from GE female mosquito saliva, informing human health risk assessments for GE mosquito pesticide registrations. This is not a NEPA document.12